The editors have included new authors and topics, and several chapters from second edition have been dropped. The overall organisation of the textbook has been changed in the light of changes of emphasis over the past 10 years. References have been restricted to create an overall succinct and comprehensive volume. 

A chapter on novel therapies in clinical trials or pre-clinical trials will be added at the time of going to press.  The editors have consolidated the gene therapy section from three to two chapters, and retitled the Section, The Future of Haemophilia Therapy.  The chapter on Old Age in Haemophilia has been extended to include more about survivorship with HCV/HIV and perioperative management (+/- anticoagulation in association with post-stent/cardiothoracic surgery following MI).